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Clinical biomarkers cancer

Aberrant glycosylation has been recognized for decades in cancer, and is now being observed in a variety of other diseases and metabolic processes. Mining the glycome for biomarkers, however, requires detailed analytical methods that can accurately profile large numbers of glycan samples from complex biological mixtures. The AGRS has developed a number of MS-based platforms for rapid processing, analysis, and identification of potential glycan disease markers.

Research highlights:
  • Rapid-throughput glycan enrichment by robotic SPE
  • Isomer-Specific LC/MS and LC/MS/MS Profiling
  • Characterization of novel glycans
  • Comprehensive native glycan profiling
  • Biomarkers discovery of infection disease and cancer
  • Identifying diagnostic and prognostic biomarkers that can be used for the detection of cancer and cancer subtypes
  • Discovery of novel specific biomarkers of infection disease and cancer

Relevant publications:
  • Lee, J., Hua, S., Lee, S.H., Oh, M.J., Yun, J.K., Kim, J.Y., Kim, J.H., Kim, J.H., An, H.J., “Designation of Fingerprint Glycopeptides for Targeted Glycoproteomic Analysis of Serum Haptoglobin: Insights into Gastric Cancer Biomarker Discovery”, Analytical and Bioanalytical Chemistry , 2018, 410(6), 1617-1629.
  • Kim, J.H., Lee, H.S., Choi, S., Kim, U., Yeo, I.S., Kim, S.H., Oh, M.J., Moon, H., Lee, J., Jeong, S., Choi, M.G., Lee, H.J., Sohn, T.S., Bae, J.M., Kim, S., Min, Y.W., Lee, H., Lee, J.H., Rhee, P.L., Kim, J.J., Lee, S.J., Kim T.S., Lee, J., Park, S.H., Park, J.O., Park, S.Y., Lim, H.Y., Kang, W.K., An, H.J., Kim, J.H., “Direct analysis of aberrant glycosylation on haptoglobin in patients with gastric cancer”, Oncotarget, 2017, 8.
  • Lee, H.S., Jeong, S.H., Lee, J., Yeo, I.S., Oh, M.J., Kim, S.M., Kim, S.H., Park, Y.S., Kim, J.H., Park, S.H., Kim H.J., An, H.J., “Glycomic profiling of targeted serum haptoglobin for gastric cancer using nano LC/MS and LC/MS/MS”, Molecular BioSystems, 2016, 12.
  • Hua, S., Saunders, M., Dimapasoc, L.M., Jeong, S.H., Kim, B.J., Lee, K.S., Kim, J.H., Lam, K.S., Lebrilla, C.B., An, H.J., “Differentiation of Cancer Cell Origin and Molecular Subtype by Plasma Membrane N-Glycan Profiling”, Journal of Proteome Research, 2014, 13(2), 961–968.
  • Kim, J.H., Park, C.W., Um, D.H., Baek, K.H., Jo, Y.H., An, H.J., Kim, Y.S., Kim, T.J., “Mass Spectrometric Screening of Ovarian Cancer with Serum Glycans”, Disease Markers , 2014.
  • Ozcan, S., Barkauskas, DA., Renee Ruhaak L., Torres, J., Cooke C.L., An, H.J., Hua, S., Williams CC., Dimapasoc, L.M., Kim J.H., Camorlinga-Ponce M., Rocke D., Lebrilla, CB., Solnick, JV., “Serum glycan signatures of gastric cancer”, Cancer Prevention Research, 2014, 7, 226-235.