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Clinical biomarkers cancer

Aberrant glycosylation has been recognized for decades in cancer, and is now being observed in a variety of other diseases and metabolic processes. Mining the glycome for biomarkers, however, requires detailed analytical methods that can accurately profile large numbers of samples(glycan, glycopeptides, glycoproteins) from complex biological mixtures. The AGRS has developed a number of MS-based platforms for rapid processing, analysis, and identification of potential glycome disease markers.

Research highlights:
  • Multi-level glycomics characterization from intact protein to native glycan
  • Rapid-throughput glycoconjugates enrichment by robotic SPE
  • Isomer-Specific LC/MS and LC/MS/MS Profiling
  • Identifying diagnostic and prognostic biomarkers that can be used for the detection of cancer and cancer subtypes
  • Discovery of novel specific biomarkers of infection disease and cancer
Relevant publications:
  • Seo, N., Lee, H.J., Oh, M.J., Kim, G.H., Lee, S.G., Ahn, J.K., Cha, H.S., Kim, K.H., Kim, J.H., An, H.J, “Isomer-specific monitoring of sialylated N-glycans reveals association of α2,3 linked sialic acid epitope with Behcet's disease”, Frontiers in molecular biosciences, 2021, In press
  • Jeong, S., Kim, U., Oh, M.J, Nam, J., Park, S., Choi, Y., Lee, D.H., Kim, J.H, An, H.J., "Detection of Aberrant Glycosylation of Serum Haptoglobin for Gastric Cancer Diagnosis Using a Middle-Up-Down Glycoproteome Platform“, Journal of Personalized Medicine, 2021, 11(6), 575.
  • Oh, M.J., Lee, S.H., Kim,U., An, H.J. “In-depth investigation of altered glycosylation in human haptoglobin associated cancer by mass spectrometry”, Mass Spectrometry Reviews, 2021 , l DOI : 10.1002/mas.21707
  • Jeong, S., Oh, M.J., Kim, U., Lee, J., Kim, J.H., An, H.J., “Glycosylation of serum haptoglobin as a marker of gastric cancer: an overview for clinicians”, Expert review of proteomics, 2020, 17(2), 109-117.
  • Lee, J., Hua, S., Lee, S.H., Oh, M.J., Yun, J.K., Kim, J.Y., Kim, J.H., Kim, J.H., An, H.J., “Designation of Fingerprint Glycopeptides for Targeted Glycoproteomic Analysis of Serum Haptoglobin: Insights into Gastric Cancer Biomarker Discovery”, Analytical and Bioanalytical Chemistry , 2018, 410(6), 1617-1629.
  • Kim, J.H., Lee, H.S., Choi, S., Kim, U., Yeo, I.S., Kim, S.H., Oh, M.J., Moon, H., Lee, J., Jeong, S., Choi, M.G., Lee, H.J., Sohn, T.S., Bae, J.M., Kim, S., Min, Y.W., Lee, H., Lee, J.H., Rhee, P.L., Kim, J.J., Lee, S.J., Kim T.S., Lee, J., Park, S.H., Park, J.O., Park, S.Y., Lim, H.Y., Kang, W.K., An, H.J., Kim, J.H., “Direct analysis of aberrant glycosylation on haptoglobin in patients with gastric cancer”, Oncotarget, 2017, 8(7), 11094.
  • Lee, H.S., Jeong, S.H., Lee, J., Yeo, I.S., Oh, M.J., Kim, S.M., Kim, S.H., Park, Y.S., Kim, J.H., Park, S.H., Kim H.J., An, H.J., “Glycomic profiling of targeted serum haptoglobin for gastric cancer using nano LC/MS and LC/MS/MS”, Molecular BioSystems, 2016, 12(2), 3611-3621.